![]() Earlier this year, AMC Studios opened a writers room for the project, which generated multiple scripts. ![]() We’re thrilled for audiences to see this bold, witty and enthralling series.”ĭispatches From Elsewhere was developed under AMC’s scripts-to-series model. “This is a very special project based on a truly unique premise and peopled by vivid characters, all driven by Jason’s wildly creative vision. “AMC has a proven history of finding shows that rise above, in every sense, and we think Dispatches from Elsewhere will be an incredible addition to that club,” said David Madden, president of original programming for AMC, SundanceTV, and AMC Studios. It also is the first TV series created by Segel who has written/co-written such movies as Forgetting Sarah Marshall, The Muppets and Sex Tape. This is Segel’s first TV role since he starred on the hit CBS comedy series How I Met Your Mother for nine seasons. ![]() Filming is slated to begin in early 2019. Segel will executive produce with Scott Rudin, Eli Bush and Garrett Basch for AMC Studios. They will come to find that the mystery winds far deeper than they ever imagined. Is available online through the link elsewhere on this page.Dispatches From Elsewhere, which will feature elements across multiple platforms, is about a group of ordinary people who stumble onto a puzzle hiding just behind the veil of everyday life. The version of record (Human Molecular Genetics, Volume 26, Issue 13, 1 July 2017, Pages 2541–2550) Publisher’s version chapter 5 Note Chapter 2 has been accepted for publication in Cancer Research, which is published by the American Association for CancerĬhapter 3 is a pre-copyedited, author-produced version of an article accepted for publication in Human Molecular Geneticsįollowing peer review. Other links Publisher’s version chapter 2 Ultimately, advancements in the understanding of rare mitochondrial diseases, following a cross-speciesĪpproach, can help to resolve the more complex processes that underlie aging and metabolic diseases. elegans knockdown of acl-3, the homologue of the human gene mutated in BTHS patients, mimicked the lipid disturbance seen in patients, establishingĪ valid model for the disease. elegans was established and utilized to detect age- and diet related changes in the nematode’s metabolome. Moreover,Ī sensitive platform to measure metabolites in C. In Barth syndrome, a disease characterized mainly by cardioskeletal myopathy, neutropenia and abnormal mitochondria,Īnd with unresolved pathophysiology, proteomic and metabolic profiling revealed altered metabolism in patient cells. ![]() In the case of the rare disease Perrault syndrome characterized by sensorineural deafnessĪnd gonadal dysgenesis, a novel mutation in the gene ERAL1 encoding a mitochondrial rRNA chaperone is identified through exome sequencing, functional mitochondrial assays and a C.Įlegans model. Organisms through targeting of mitochondrial translation their use in research as a tool to control gene expression may thereforeĬonfound the experimental outcome. Mitochondrial function affects organismal physiology is given by the profound effects of tetracycline antibiotics on various elegans as a model for resolving the relationship between metabolism, aging and mitochondrial disease. Of mitochondria in specific cases of rare inherited metabolic diseases, and to establish the nematode C. Aims of this thesis were to study the role Mitochondria are intracellular organelles that play a central role in metabolism. ![]()
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